Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.

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dc.contributor.authorLiu, Zhigang
dc.contributor.authorDai, Xiaoshuang
dc.contributor.authorZhang, Hongbo
dc.contributor.authorShi, Renjie
dc.contributor.authorHui, Yan
dc.contributor.authorJin, Xin
dc.contributor.authorZhang, Wentong
dc.contributor.authorWang, Luanfeng
dc.contributor.authorWang, Qianxu
dc.contributor.authorWang, Danna
dc.contributor.authorWang, Jia
dc.contributor.authorTan, Xintong
dc.contributor.authorRen, Bo
dc.contributor.authorLiu, Xiaoning
dc.contributor.authorZhao, Tong
dc.contributor.authorWang, Jiamin
dc.contributor.authorPan, Junru
dc.contributor.authorYuan, Tian
dc.contributor.authorChu, Chuanqi
dc.contributor.authorLan, Lei
dc.contributor.authorYin, Fei
dc.contributor.authorCadenas, Enrique
dc.contributor.authorShi, Lin
dc.contributor.authorZhao, Shancen
dc.contributor.authorLiu, Xuebo
dc.date.accessioned2024-08-23T18:36:07Z
dc.date.issued2020-02-18
dc.description.abstractCognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.
dc.identifier.citationLiu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., Zhang, W., Wang, L., Wang, Q., Wang, D., Wang, J., Tan, X., Ren, B., Liu, X., Zhao, T., Wang, J., Pan, J., Yuan, T., Chu, C., … Liu, X. (2020). Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications, 11(1), 855–855. https://doi.org/10.1038/s41467-020-14676-4
dc.identifier.urihttps://doi.org/10.1038/s41467-020-14676-4
dc.identifier.urihttps://demo.dspace.org/handle/123456789/1137
dc.language.isoen
dc.publisherSpringer Nature
dc.subjectNATURAL SCIENCES::Chemistry::Biochemistry
dc.subjectMEDICINE::Morphology, cell biology, pathology::Cell biology::Neuroscience
dc.subjectNATURAL SCIENCES::Biology::Organism biology::Microbiology
dc.titleGut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.
dc.typeArticle

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